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Alesis iO4 in Reaper, headphones output not working

I'm setting up my Alesis iO4 in Reaper. I can't find a way to output the program sounds to my headphones plugged into the interface. The outputs just say iO4 1-4, but none of those playback recorded sound from Reaper, I've set the mix to USB and still can't hear anything. The audio is definitely playing back because I can see the level, but I can't output it through my headphones for some reason. Any ideas?
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